Cross-cultural sex differences in mobility and harm avoidance have been widely reported, often emphasizing fitness benefits of long-distance travel for males and high costs for females. Data emerging from adults in small-scale societies, however, are challenging the assumption that female mobility is restricted during reproduction. Such findings warrant further exploration of the ontogeny of mobility. Here, using a combination of machine-learning, mixed-effects linear regression, and GIS mapping, we analyze range size, daily distance traveled, and harm avoidance among Hadza foragers (...) during middle childhood and adolescence. Distance traveled increased with age and, while male adolescents had the longest daily ranges, average daily distance traveled by each sex was similar. We found few age- or sex-related patterns in harm-avoidant responses and a high degree of individual variation. When queried on the same issues, children and their parents were often in alignment as to expectations pertaining to harm avoidance, and siblings tended to behave in similar ways. To the extent that sex differences in mobility did emerge, they were associated with ecological differences in physical threats associated with sex-specific foraging behaviors. Further, we found no strong association between harm avoidance and mobility. Young Hadza foragers of both sexes are highly mobile, regardless of how harm avoidant they are. Taken together, our findings indicate that the causal arrows between harm avoidance and mobility must be evaluated in ecologically specific frameworks where cultural expectations of juvenile mobility can be contextualized. (shrink)

Model organisms are central to contemporary biology and studies of embryogenesis in particular. Biologists utilize only a small number of species to experimentally elucidate the phenomena and mechanisms of development. Critics have questioned whether these experimental models are good representatives of their targets because of the inherent biases involved in their selection (e.g., rapid development and short generation time). A standard response is that the manipulative molecular techniques available for experimental analysis mitigate, if not counterbalance, this concern. But the (...) most powerful investigative techniques and molecular methods are applicable to single-celled organisms (‘microbes’). Why not use unicellular rather than multicellular model organisms, which are the standard for developmental biology? To claim that microbes are not good representatives takes us back to the original criticism leveled against model organisms. Using empirical case studies of microbes modeling ontogeny, we break out of this circle of reasoning by showing: (a) that the criterion of representation is more complex than earlier discussions have emphasized; and, (b) that different aspects of manipulability are comparable in importance to representation when deciding if a model organism is a good model. These aspects of manipulability harbor the prospect of enhancing representation. The result is a better understanding of how developmental biologists conceptualize research using experimental models and suggestions for underappreciated avenues of inquiry using microbes. More generally, it demonstrates how the practical aspects of experimental biology must be scrutinized in order to understand the associated scientific reasoning. (shrink)

This paper is a report of an empirical psychological study of the relationship between the ethical and financial beliefs and desires of ethical investors. Semi-structured interviews of 20 ethical investors have been carried out by the project 10 of which have been analysed using qualitative data analysis software. All of our participants faced the problem that, while they had ethical concerns, they were not prepared to sacrifice their essential financial requirements to address them. We found four common ways of dealing (...) with this problem: they divided up their money into core and surplus accounts; they decided that it was enough to only be a partial ethical investor; they avoided detailed consideration of the costs of ethical investment; and they avoided rigorous ethical thinking. One equilibrium position arising from these responses is a portfolio approach to ethics, which allows people to assuage their consciences by investing only a small proportion of their investments ethically, while leaving the rest in non-ethical investment vehicles. (shrink)

“Life exists only at this very moment, and in this moment it is infinite and eternal. For the present moment is infinitely small; before we can measure it, it has gone, and yet it exists forever…. You may believe yourself out of harmony with life and its eternal Now; but you cannot be, for you are life and exist Now.”–from Become What You Are In this collection of writings, including nine new chapters never before available in book form, Watts (...) displays the intelligence, playfulness of thought, and simplicity of language that has made him so perennially popular as an interpreter of Eastern thought for Westerners. He draws on a variety of religious traditions, and covers topics such as the challenge of seeing one’s life “just as it is,” the Taoist approach to harmonious living, the limits of language in the face of ineffable spiritual truth, and the psychological symbolism of Christian thought. (shrink)

A decade ago, Harris Nover and I introduced the Pasadena game, which we argued gives rise to a new paradox in decision theory even more troubling than the St Petersburg paradox. Gwiazda's and Smith's articles in this volume both offer revisionist solutions. I critically engage with both articles. They invite reflections on a number of deep issues in the foundations of decision theory, which I hope to bring out. These issues include: some ways in which orthodox decision theory might be (...) supplemented; the role of simulations of such infinite games; the role of small probabilities, and of idealization, in decision theory; tolerance about practical norms; and alternative ways of understanding decision theory's job description. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users. (shrink)

This paper (i) gives necessary and sufficient conditions that clocks in an inertial lattice can be synchronized, (ii) shows that these conditions do not imply a universal light speed, and (iii) shows that the terrestrial redshift experiment provides evidence that clocks in a small inertial lattice in a gravitational field can be synchronized.

This paper is based on two separate, though partly overlapping, registers of male Athenian citizens known to have been in the public eye between theyears 432/1 and 405/4 B.C., inclusive. Register I comprises those who are known inthis period to have held important elective public office, or to have proposed andcarried resolutions in the Assembly; a total of 176 persons. These are singled out fromthe much wider range of ‘officials’, most of them chosen by lot, to be found in theprosopography (...) of Develin 1989, because they are those who actively, and in somemeasure successfully, competed for the political favour of the Athenian public. Theimportant elective public offices I take to be those of general, proboulos , member of any embassy, and delegate for swearing to an international treaty. Register II comprises those who are known in this period to have been referred to asindividuals in Athenian comedies; a total of 224 persons. Both lists inevitably havesomewhat fuzzy edges, mainly over questions of identification and dating; doubtfulcases are briefly discussed in the notes to the Registers. Probably no other scholar willagree with every one of my decisions in these matters, but the general validity of thepicture here presented is unlikely to be affected. Within Register II can be identifiedtwo small but important subgroups: those who are referred to not, as is normal, fordisparagement but for praise; and those to whom is devoted an entire play or a largepart of one. I will be returning to these. (shrink)

Whereas many environmentalists have traditionally argued in favour of small‐scale, decentralised communities as a solution to the environmental crises which we appear to face, some environmental political theorists have recently argued against decentralisation. In this article I first show that game theory seems, at first glance, to support the insistence by statists that decentralisation is highly impracticable. But, second, I then attempt to demonstrate that, on closer inspection, game theory actually provides considerable support for the decentralist case.

In lieu of an abstract, here is a brief excerpt of the content:Transgressing the Boundaries: An Afterword*Alan D. SokalAlas, the truth is out: my article, “Transgressing the Boundaries: Toward a Transformative Hermeneutics of Quantum Gravity,” which appeared in the spring/summer 1996 issue of the cultural-studies journal Social Text, is a parody. 1 Clearly I owe the editors and readers of Social Text, as well as the wider intellectual community, a non-parodic explanation of my motives and my true views. One (...) of my goals here is to make a small contribution toward a dialogue on the Left between humanists and natural scientists—“two cultures” which, contrary to some optimistic pronouncements (mostly by the former group), are probably farther apart in mentality than at any time in the past fifty years.Like the genre it is meant to satirize—myriad exemplars of which can be found in its reference list—my article is a mélange of truths, half-truths, quarter-truths, falsehoods, non sequiturs, and syntactically correct sentences that have no meaning whatsoever. (Sadly, there are only a handful of the latter: I tried hard to produce them, but I found that, save for rare bursts of inspiration, I just didn’t have the knack.) I also employed some other strategies that are well-established (albeit sometimes inadvertently) in the genre: appeals to authority in lieu of logic; speculative theories passed off as established science; strained and even absurd analogies; rhetoric that sounds good but whose meaning is [End Page 338] ambiguous; and confusion between the technical and everyday senses of English words (for example: linear, nonlinear, local, global, multidimensional, relative, frame of reference, field, anomaly, chaos, catastrophe, logic, irrational, imaginary, complex, real, equality, choice).I should emphasize that all works cited in my article are real, and all quotations are rigorously accurate; none are invented. Indeed, the most hilarious passages in my article were not written by me: they are direct quotes from the Masters.But why did I do it? I confess that I’m an unabashed Old Leftist who never quite understood how deconstruction was supposed to help the working class. And I’m a stodgy old scientist who believes, naively, that there exists an external world, that there exist objective truths about that world, and that my job is to discover some of them. (If science were merely a negotiation of social conventions about what is agreed to be “true,” why would I bother devoting a large fraction of my all-too-short life to it? I don’t aspire to be the Emily Post of quantum field theory.)But my main concern isn’t to defend science from the barbarian hordes of lit crit. Rather, my concern is explicitly political: to combat a currently fashionable postmodernist/poststructuralist/social-constructivist discourse—and more generally a penchant for subjectivism—which is, I believe, inimical to the values and future of the Left. 2 Alan Ryan said it well:It is, for instance, pretty suicidal for embattled minorities to embrace Michel Foucault, let alone Jacques Derrida. The minority view was always that power could be undermined by truth.... Once you read Foucault as saying that truth is simply an effect of power, you’ve had it.... But American departments of literature, history and sociology contain large numbers of self-described leftists who have confused radical doubts about objectivity with political radicalism, and are in a mess. 3Likewise, Eric Hobsbawm has decriedthe rise of “postmodernist” intellectual fashions in Western universities, particularly in departments of literature and anthropology, which imply that all “facts” claiming objective existence are simply intellectual constructions. In short, that there is no clear difference between fact and fiction. But there is, and for historians, even for the most militantly antipositivist ones among us, the ability to distinguish between the two is absolutely fundamental. 4 [End Page 339](Hobsbawm goes on to show how rigorous historical scholarship can refute the fictions propounded by reactionary nationalists in India, Israel, the Balkans and elsewhere.) And as the acerbic sociologist Stanislav Andreski noted long ago,So long as authority inspires awe, confusion and absurdity enhance conservative tendencies in society. Firstly, because clear and logical thinking leads to a cumulation of knowledge (of which the progress of... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:48 SOME CQUHSEL ON HUMEAN RELATIONS In a paper published eight years ago I tried to bring out a neglected feature of Hume's theory of relations, namely the difference between philosophical and natural re1 2. lations. Now Ijnlay, without referring to my work, has expanded some of its themes in an extremely interesting and, I think, important way. At least he has made me rethink the whole distinction between (...) philosophical and natural relations and, what goes with relation theory, Hume's analytic-synthetic distinction. The strengths of his paper are, embarrassingly, the weaknesses of my own. I did not articulate clearly the connection between relation theory in Hume and the analytic-synthetic distinction. I shall turn to these strengths presently. My focus in this paper, however, will be on a central weakness in Imlay 's; and the point, it turns out, is one I gave full credence to earlier. Imlay does not distinguish what in Hume can and must be distinguished if we are to make any sense (let alone full sense) of his theory of causation. The distinction is be3 tweer, necessity and certainty. In trying to explicate Hume's distinction between intuitive and demonstrative inference on the one hand, and probability on the other, Imlay finally reaches an impasse. For, if the absence of the corresponding impression does not deprive mathematical necessity of... existence, why should it do so in the case of causal necessity? This, as Imlay recognizes, is at least related to standard criticisms of Hume, most forcibly articulated by Prichard. Imlay fortunately does not recommend—as Prichard does — throwing out the baby with the bath. If I understand him correctly, what he advocates is that we simply admit that Hume's attempts to ground necessity are inadequate. Before proceeding to details, let me issue two brief caveats. 49 First. It is of course not surprising that Hume fails to make a clear analytic-synthetic distinction. Has anyone? Lacking the logical tools of a Russell, or the mathematical understanding of a Leibniz, Hume labors under insuperable difficulties which, in many instances, are selfcreated. He is not clear as to whether necessity attaches to 'objects' or ideas (let alone sentences or propositions); he confuses, by invoking pseudo-psychological criteria involving conceivability, analytic with synthetic a priori truths; he has what many, including myself, consider to be a ludicrous theory about mathematics and mathematical objects. With these horrors to work with it is small wonder that necessity never gets grounded. Indeed, it is miraculous that the discussion even gets off the ground. But, Prichard's sneeringly just comments notwithstanding, both he and Imlay miss something, and I hope to show precisely what that is. Second. Hume is notoriously obscure in his discussion of what we would call ordinary physical objects. Sometimes (when he is in a psychologist or even ordinaryperson mood) he speaks as if physical objects cause impressions. Sometimes (when in the philosopher's closet) he speaks as if it makes no sense to speak of anything but impressions and collections of them, ordinary physical objects being relegated to the fictions of the vulgar. His theory of relations rather obviously suffers from the same disease; it is not clear what the relata are. Are impressions related temporally? Spatially? Is it relations between objects 'out there' of which he speaks when he discusses causation? Imlay is quite aware of the confusion ; he just lets it go. For now, I shall more or less follow suit. Later, as we shall see, one's choice makes a difference. In the long run, I think any coherent view of Hume will have to treat his analysis of physical objects in a way similar to Berkeley's · I. Hume, Prichard, and Imlay At first glance it would seem easy to allay at least Prichard' s fears. What, after all, is the connection between Hume's theory of relations, his attempt at distinguishing the necessary from the probable or possible, and his theory of causation? Hume claims that causation is a relation that, unlike some others, eg., resemblance, cannot be 'seen' to hold between its relata. But all of us believe that causal connections are necessary. Why do we all believe what... (shrink)

During the past decade, it has become apparent that it is within our grasp to understand fully the development and functioning of complex organisms. It is widely accepted that this undertaking must include the elucidation of the genetic blueprint – the genome sequence – of a number of model organisms. As a prelude to the determination of these sequences, clonebased physical maps of the genomes of a number of multicellular animals and plants are being constructed. Yeast artificial chromosome (YAC) vectors, (...) by virtue of their relatively unbiased cloning capabilities and capacity to carry large inserts, have come to play a central role in the construction of these maps. The application of YACs to the physical map of the Caenorhabditis elegans genome has enabled cosmid clone ‘islands’ to be linked together in an efficient manner. The long‐range continuity has improved the linkage between the genetic and physical maps, greatly increasing its utility. Since the genome can be represented by a relatively small number of YACs, it has been possible to make replica filters of genomically ordered YACs available to the community at large. (shrink)

This paper is based on two separate, though partly overlapping, registers (Registers I and II) of male Athenian citizens known to have been in the public eye between theyears 432/1 and 405/4 B.C., inclusive. Register I comprises those who are known inthis period to have held important elective public office, or to have proposed andcarried resolutions in the Assembly; a total of 176 persons. These are singled out fromthe much wider range of ‘officials’, most of them chosen by lot, to (...) be found in theprosopography of Develin 1989, because they are those who actively, and in somemeasure successfully, competed for the political favour of the Athenian public. Theimportant elective public offices I take to be those of general, proboulos (in 413–411), member of any embassy, and delegate for swearing to an international treaty. Register II comprises those who are known in this period to have been referred to asindividuals in Athenian comedies; a total of 224 persons. Both lists inevitably havesomewhat fuzzy edges, mainly over questions of identification and dating; doubtfulcases are briefly discussed in the notes to the Registers. Probably no other scholar willagree with every one of my decisions in these matters, but the general validity of thepicture here presented is unlikely to be affected. Within Register II can be identifiedtwo small but important subgroups: those who are referred to not, as is normal, fordisparagement but for praise; and those to whom is devoted an entire play or a largepart of one. I will be returning to these. (shrink)

Which is worse: Doing evil or being evil? If we are free to define ourselves through our choices, as existentialism posits, then the latter is worse. This paper attempts to resolve the issue of the difference between religious (group) ethics and the ethics of a person of faith that embraces individuals with an existential understanding. In the existential view, the individual (whether the self or the other) is the primary concern, and so the issue of personal relational morality supersedes religious (...) narratives, social morality and popular ethics (White, 2002). If we think and choose, there is the possibility that we may occasionally make a mistake and do evil. However, if we do not think about our choices, and if the conventions we hold happen to be flawed in some way, then we become defined by a continual cycle of mistakes. Existentialism teaches that we become who we are in the process of making choices; therefore the difference between doing evil and being evil can be found in the small but important flow of thinking, relating and choosing. (shrink)

A founder event occurs when a new population is established from a small number of individuals drawn from a large ancestral population. Mayr proposed that genetic drift in an isolated founder population could alter the selective forces in an epistatic system, an observation supported by recent studies. Carson argued that a period of relaxed selection could occur when a founder population is in an open ecological niche, allowing rapid population growth after the founder event. Selectable genetic variation can actually (...) increase during this founder‐flush phase due to recombination, enhanced survival of advantageous mutations, and the conversion of non‐additive genetic variance into additive variance in an epistatic system, another empirically confirmed prediction. Templeton combined the theories of Mayr and Carson with population genetic models to predict the conditions under which founder events can contribute to speciation, and these predictions are strongly confirmed by the empirical literature. Much of the criticism of founder speciation is based upon equating founder speciation to an adaptive peak shift opposed by selection. However, Mayr, Carson and Templeton all modeled a positive interaction of selection and drift, and Templeton showed that founder speciation is incompatible with peak‐shift conditions. Although rare, founder speciation can have a disproportionate importance in adaptive innovation and radiation, and examples are given to show that “rare” does not mean “unimportant” in evolution. Founder speciation also interacts with other speciation mechanisms such that a speciation event is not a one‐dimensional process due to either selection alone or drift alone. BioEssays 30:470–479, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The ArgumentMany associations have recently been discovered between phenotypic variation and genetic loci, causing some to advocate what Robert Sinsheimer has called “a new eugenics” that would treat genetic “defects” in individuals prone to a disease. The first premise of this vision is that genetic association studies reveal the biological cause of the phenotypic variation. Once the responsible genes are known, the second premise is that we should focus upon changing “nature” rather than “nurture” by correcting the “defective” genes.The first (...) premise is flawed because associations between genetic markers and phenotypes can be spurious, as shown by an example. Moreover, it is shown that using non-causative but associated genetic markers one at a time (the normal practice) can lead to incorrect predictions of disease risk for many individuals. Going from association to causation is a non-trivial step scientifically that has rarely been done in much of the human genetic research.Even when a particular locus does contribute to the phenotypic variation of interest, the first premise remains flawed because phenotypes in general arise from complex interactions among genes and between genes and environments as shown for genes associations with coronary artery disease (CAD). The ability of current molecular genetic tools to “fix” defective genotypes is extremely limited, but even if the technological problems could be overcome, the studies on CAD reveal no obvious “defective” gene to fix because the genetic effects are so context dependent (upon both other genes and environmental factors). Contrary to the second premise of the new eugenics, the more we learn about how different genotypes show variable responses to environments, themoreimportant the environment becomes for individual treatment.The paradigm of a “defective gene” may work for classical Mendelian genetic diseases that are due to loss-of-function mutations. However, such mutations affect only a small portion of humanity. When the focus is changed to common disease and behavioral phenotypes, the “defective gene” paradigm is biologically meaningless and often harmful when applied to individuals. Thus, even when genes clearly do influence common phenotypic variation, the premises of the “new eugenics” are biologically indefensible. (shrink)

We construct a model in which the splitting number is large and every ultrafilter has a small subset with no pseudo-intersection.

In London in 1993, a black teenager named Stephen Lawrence was fatally stabbed by a small gang of white teenagers. His friend Duwayne Brooks was a witness but the police failed to take his testimony seriously. When someone speaks but is not heard because of accent, sex, or colour, that person is undermined as a knower. This week, we look at was it means to do justice to someone's status as a knower.

In her recent article, Does autonomy count in favor of labeling genetically modified food?, Kirsten Hansen argues that in Europe, voluntary negative labeling of non-GM foods respects consumer autonomy just as well as mandatory positive labeling of foods with GM content. She also argues that because negative labeling places labeling costs upon those consumers that want to know whether food is GM, negative labeling is better policy than positive labeling. In this paper, we argue that Hansens arguments are mistaken in (...) several respects. Most importantly, she underestimates the demands of respecting autonomy and overestimates the cost of positive labeling. Moreover, she mistakenly implies that only a small minority of people desire information about GM content. We also explore the extent to which her arguments would apply to the US context, and argue that any discussion of the relationship between autonomy and labeling should include not just considerations of consumer autonomy but also considerations of what we call citizen autonomy. (shrink)

This paper is a report of an empirical psychological study of the relationship between the ethical and financial beliefs and desires of ethical investors. Semi-structured interviews of 20 ethical investors have been carried out by the project 10 of which have been analysed using qualitative data analysis software. All of our participants faced the problem that, while they had ethical concerns, they were not prepared to sacrifice their essential financial requirements to address them. We found four common ways of dealing (...) with this problem: they divided up their money into core and surplus accounts; they decided that it was enough to only be a partial ethical investor; they avoided detailed consideration of the costs of ethical investment; and they avoided rigorous ethical thinking. One equilibrium position arising from these responses is a portfolio approach to ethics, which allows people to assuage their consciences by investing only a small proportion of their investments ethically, while leaving the rest in non-ethical investment vehicles. (shrink)

This study examines the direct impact of three dimensions of the institutional environment on managerial attitudes toward the natural environment and the direct influence of the latter on the environmental sustainability orientation (ESO) of small firms. We contend that when the institutional environment is perceived by owner–managers as supportive of sound natural environment management practices, they are more likely to develop a positive attitude toward natural environment issues and concerns. Such owner–manager attitudes are likely to lead to a positive (...) and proactive orientation of their firms toward environmental sustainability. The study uses survey data from 166 small manufacturing firms located in three Philippine cities. First, the study develops and tests the measurement models to examine the validity of the constructs representing the firm’s institutional environment, managerial attitudes toward the natural environment and the ESO of firms. Second, the study develops and tests the structural models examining the institutional environment–managerial attitudes–ESO linkages. Multi-sample invariance structural model analysis shows the mediating role of managerial attitudes in the institutional environment–ESO nexus. The findings show that ESO is a construct comprising three dimensions: knowledge of environmental issues, sustainable practices and commitment toward environmental sustainability. The cognitive, regulatory and normative elements of the institutional environment are strongly linked to positive managerial attitudes toward environmental sustainability, which in turn, positively influences the firm’s overall ESO. Managerial attitudes play a mediating role in the institutional environment–ESO linkages. The managerial, practical, research and policy implications of the research findings are discussed. (shrink)

This is a simple essay. It raises a familiar question about equality, adduces a very small amount of empirical evidence about the social consequences of equality as distinct from prosperity, and broods on the difficulty of providing a really persuasive answer to the question raised. I begin with the view that there simply cannot be anything intrinsically wrong with inequality, move on to the view that there are extrinsic reasons for anxiety, dividing these into conceptual and empirical reasons, though (...) without any great commitment to the clarity of that distinction in this context, and end with some reflections on recent social and political theory. The essay thus begins with what I hope are clear and (what I am sure are) very simple thoughts, before muddying the water pretty thoroughly thereafter. (shrink)

This paper is a small contribution to two large subjects. The first large subject is that of exploitation—what it is for somebody to be exploited, in what ways people can be and are exploited, whether exploitation necessarily involves coercion, what Marx's understanding of exploitation was and whether it was adequate: all these are issues on which I merely touch, at best. My particular concern here is to answer the two questions, whether Marx thought capitalist exploitationunjustand how the answer to (...) that question illuminates Marx's conception of morality in general. The second large subject is that of the nature of morality—whether there are specificallymoralvalues and specifically moral forms of evaluation and criticism, how these relate to our explanatory interests in the same phenomena, what it would be like to abandon the ‘moral point of view’, whether the growth of a scientific understanding of society and ourselves inevitably undermines our confidence in the existence of moral ‘truths’. These again are issues on which I only touch if I mention them at all, but the questions I try to answer are, what does Marx propose to put in the place of moral judgment, and what kind of assessment of the horrors of capitalism does he provide if not a moral assessment? (shrink)

This paper is a small contribution to two large subjects. The first large subject is that of exploitation—what it is for somebody to be exploited, in what ways people can be and are exploited, whether exploitation necessarily involves coercion, what Marx's understanding of exploitation was and whether it was adequate: all these are issues on which I merely touch, at best. My particular concern here is to answer the two questions, whether Marx thought capitalist exploitationunjustand how the answer to (...) that question illuminates Marx's conception of morality in general. The second large subject is that of the nature of morality—whether there are specificallymoralvalues and specifically moral forms of evaluation and criticism, how these relate to our explanatory interests in the same phenomena, what it would be like to abandon the ‘moral point of view’, whether the growth of a scientific understanding of society and ourselves inevitably undermines our confidence in the existence of moral ‘truths’. These again are issues on which I only touch if I mention them at all, but the questions I try to answer are, what does Marx propose to put in the place of moral judgment, and what kind of assessment of the horrors of capitalism does he provide if not a moral assessment? (shrink)

A suite of technological advances based on nanotechnology has received substantial attention for its potential to affect privacy. Reports of the National Nanotechnology Initiative have recognized that the societal implications of nanotechnology will include better surveillance and information-gathering technologies. A variety of academic and popular publications have explained the potential effects of nanotechnology on privacy.The ways in which nanotechnology might affect privacy are varied. It may make current information technology better, make old information-gathering techniques more reliable, or expand information-gathering into (...) novel areas. My focus in this paper is on the privacy effects of one potential application of nanotechnology: sensors capable of detecting weapons agents or drugs—"nanosensors" or "sensors" for short. Nanotechnology may make possible small, accurate, and easy-to-use sensors to detect a variety of substances, including Chemical, Biological, Radiological, and Explosive agents , as well as drugs. Analyzing the potential effects on privacy of sensors can provide important insights into the nature and extent of privacy rights. (shrink)

Disrespect in health care often persists despite firm commitments to respectful service provision. This conceptual paper highlights how the ways in which respect and disrespect are characterised can have practical implications for how well disrespect can be tackled. We stress the need to focus explicitly on disrespect (not only respect) and propose that disrespect can usefully be understood as a failure to relate to people as equals. This characterisation is consonant with some accounts of respect but sometimes obscured by a (...) focus on respecting people’s autonomy and dignity. Emphasising equality is consistent with connections patients draw between being (dis)respected and (in)equality. It readily accommodates microaggressions as forms of disrespect, helping to understand how and why experiences of disrespect may be unintentional and to explain why even small instances of disrespect are wrong. Our view of disrespect with an emphasis on equality strengthens the demand that health systems take disrespect seriously as a problem of social injustice and tackle it at institutional, not just individual levels. It suggests several strategies for practical action. Emphasising relational equality is not an easy or short-term fix for disrespect, but it signals a direction of travel towards an important improvement ambition. (shrink)

“Busyness” like many concepts trades on contrast. The most obvious contrast is with “real work” and ‘really working.” “Busy work” is usually pretend work; we try to look as though we are achieving something but all we are doing is shuffling the paper on our desks, polishing the inlet manifold rather than diagnosing the fault about to destroy the engine, marching our soldiers up to the top of the hill and marching them down again rather than engaging the enemy. All (...) the same, being “busy” is often said to be a good thing: the Puritan hymn writer Isaac Watts celebrated “the little busy bee” for improving the shining hour. For creatures other than the bee, busy may be a good thing to be but not usually the best thing: a midfield soccer player who is “busy” is useful, but a player of equal skill who is “economical” is better. My theme is that our attitude to “real work” is deeply ambiguous; on the one side, work is a curse, the labour to which we are doomed as a result of the Fall; its side-effect of enforcing upon us a necessary discipline and self-discipline is small consolation. On the other side, work is the expression of distinctive human powers and aspirations; work brings imagination into the world as well as drudgery. We imagine a world that does not exist but might, and then we set about creating it. The Fall was a happy Fall, and the need to labour was the first step in teaching the human species how to make the most of its potentialities. (shrink)

Ontologies are being used increasingly to promote the reusability of scientific information by allowing heterogeneous data to be integrated under a common, normalized representation. Definitions play a central role in the use of ontologies both by humans and by computers. Textual definitions allow ontologists and data curators to understand the intended meaning of ontology terms and to use these terms in a consistent fashion across contexts. Logical definitions allow machines to check the integrity of ontologies and reason over data annotated (...) with ontology terms to make inferences that promote knowledge discovery. Therefore, it is important not only to include in ontologies multiple types of definitions in both formal and in natural languages, but also to ensure that these definitions meet good quality standards so they are useful. While tools such as Protégé can assist in creating well-formed logical definitions, producing good definitions in a natural language is still to a large extent a matter of human ingenuity supported at best by just a small number of general principles. For lack of more precise guidelines, definition authors are often left to their own personal devices. This paper aims to fill this gap by providing the ontology community with a set of principles and conventions to assist in definition writing, editing, and validation, by drawing on existing definition writing principles and guidelines in lexicography, terminology, and logic. (shrink)

The publication in France of our book Impostures Intellectuelles [1] appears to have created a small storm in certain intellectual circles. According to Jon Henley in The Guardian, we have shown that ``modern French philosophy is a load of old tosh.''[2] According to Robert Maggiori in Libération, we are humourless scientistic pedants who correct grammatical errors in love letters.[3] We shall try to explain here why neither is the case.

The stratum-specific treatment effect function is a random variable giving the average treatment effect (ATE) for a randomly drawn stratum of potential confounders a clinician may use to assign treatment. In addition to the ATE, the variance of the stratum-specific treatment effect function is fundamental in determining the heterogeneity of treatment effect values. We offer a non-parametric plug-in estimator, the targeted maximum likelihood estimator (TMLE) and the cross-validated TMLE (CV-TMLE), to simultaneously estimate both the average and variance of the stratum-specific (...) treatment effect function. The CV-TMLE is preferable because it guarantees asymptotic efficiency under two conditions without needing entropy conditions on the initial fits of the outcome model and treatment mechanism, as required by TMLE. Particularly, in circumstances where data adaptive fitting methods are very important to eliminate bias but hold no guarantee of satisfying the entropy condition, we show that the CV-TMLE sampling distributions maintain normality with a lower mean squared error than TMLE. In addition to verifying the theoretical properties of TMLE and CV-TMLE through simulations, we highlight some of the challenges in estimating the variance of the treatment effect, which lack double robustness and might be biased if the true variance is small and sample size insufficient. (shrink)

The recent essay by Schuklenk and Smalling opposing respect for physicians’ conscientious objections to providing patients with medical services that are legally permitted in liberal democracies is based on several erroneous assumptions. Acting in this manner would have serious harmful effects on the ethos of medicine and of bioethics. A much more nuanced and balanced position is critical in order to respect physicians’ conscience with minimal damage to patients’ rights.

If we set aside personal edification, what reasons remain for a philosopher of science to study the intellectual biography of a famous (or infamous) scientist? This question raises familiar and perhaps tired arguments about the relationship between history of science and philosophy of science, but it is also practical: why take the time to digest almost 600 pages devoted to the controversial German zoologist Ernst Haeckel? A preliminary answer is the author. The historical investigations of Robert Richards have been of (...) ongoing interest to philosophers, whether it be evolutionary explanations of mind and behavior in the nineteenth century (Dennett 1989) or his contentious claims—reinvigorated in the present volume—about Darwin’s commitment to embryonic recapitulation (Lennox 1994). Richards has a knack for unearthing details germane to conceptual reflection, in no small part because of his own philosophical predilections (e.g., a selection model of scientific theory development). Here I entertain three more reasons to follow the injunction tolle lege: the prescient synthesis exemplified in Haeckel’s evolutionary theorizing, the impact of model organism choice, and the critical role of pictures in scientific reasoning accented by Haeckel’s artistic proclivities. (shrink)

Although the last decade has seen a proliferation of ontological approaches to arguments, many of them employ ad hoc solutions to representing arguments, lack interoperability with other ontologies, or cover arguments only as part of a broader approach to evidence. To provide a better ontological representation of arguments, we present the Arguments Ontology (ArgO), a small ontology for arguments that is designed to be imported and easily extended by researchers who work in different upper-level ontology frameworks, different logics, and (...) different approaches to argument evaluation. Unlike most ontological approaches to arguments, ArgO utilizes Basic Formal Ontology (BFO) as an upper-level ontology, and may be used alongside other commonly used ontologies in the BFO framework, including boththe Information Artifact Ontology (IAO), and the Information Entity Ontology (INFO). Critically, our proposal is principled, based on rigorous definitions and formal axioms out of which characterizations of arguments naturally fall. It is our hope that ArgO may assist researchers in many projects, including: integrating heterogeneous sources of evidence, structuring the content of semantic wikis, and enhancing semantic reasoning. (shrink)

Death from cancer is usually due to metastasis. Fortunately, most cells that escape from a primary tumor fail to form metastases. Identifying reasons for this failure will help development of anti‐metastatic therapies. Intravital videomicroscopy (IVVM) can be used to observe cancer cells injected into live animals. Co‐injected microspheres can be used to assess cell survival. These techniques have been used to show that circulating tumor cells generally arrest in the microcirculation and may extravasate with high efficiency. While many tumor cells (...) may survive in a secondary site, only a small subset form micrometastases and only a subset of these micrometastases persist to form vascularized macrometastases. Furthermore, solitary tumor cells may remain dormant for long periods of time in secondary sites. These findings suggest that metastatic growth and angiogenesis are prime targets for anti‐metastatic therapy. BioEssays 24:885–893, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

The introduction of Philosophy and Ethics to the Western Australian Certificate of Education courses in 2008 brought philosophy into the Western Australian secondary school curriculum for the first time. How philosophy came to be included is part of a larger story about the commitment and perseverance of a relatively small number of Australian educators and their belief in the value of introducing philosophical communities of inquiry into school classrooms through a revised pedagogy which could sit comfortably with an outcomes-based (...) education system. (shrink)

Rho, a member of the Ras superfamily of small GTPases, has multiple biological roles: it regulates signal trasduction pathways linking extracellular growth factors to the assembly of actin stress fibres and focal adhesion complexes; it is required for G1 progression and activates the SRF transcription factor when quiescent fibroblasts are stimulated to grow; and it plays a role later in the cell cycle during cytokinesis. Two groups have recently succeeded in identifying downstream effectors of Rho that may mediate some (...) of these biological effects. One protein identified by both groups is protein kinase N (PKN), a serine/threonine kinase whose catalytic domain is closely related to that of protein kinase C(1,2). (shrink)

Home births entail a definite small risk, of unknown magnitude. Hospital births entail a wider range of risks, whose magnitude may be large but is also unknown. The morality of home births should be decided on a case‐by‐case basis, according to these priorities: safety of the mother, safety of the fetus, benefit to the fetus, potential benefit to the mother.

Which is worse: Doing evil or being evil? If we are free to define ourselves through our choices, as existentialism posits, then the latter is worse. This paper attempts to resolve the issue of the difference between religious (group) ethics and the ethics of a person of faith that embraces individuals with an existential understanding. In the existential view, the individual (whether the self or the other) is the primary concern, and so the issue of personal relational morality supersedes religious (...) narratives, social morality and popular ethics (White, 2002). If we think and choose, there is the possibility that we may occasionally make a mistake and do evil. However, if we do not think about our choices, and if the conventions we hold happen to be flawed in some way, then we become defined by a continual cycle of mistakes. Existentialism teaches that we become who we are in the process of making choices; therefore the difference between doing evil and being evil can be found in the small but important flow of thinking, relating and choosing. (shrink)

Review of extant research on the corporate environmental performance (CEP) and corporate financial performance (CFP) link generally demonstrates a positive relationship. However, some arguments and empirical results have demonstrated otherwise. As a result, researchers have called for a contingency approach to this research stream, which moves beyond the basic question “does it pay to be green?” and instead asks “when does it pay to be green?” In answering this call, we provide a meta-analytic review of CEP–CFP literature in which we (...) identify potential moderators to the CEP–CFP relationship including environmental performance type (e.g., reactive vs. proactive performance), firm characteristics (e.g., large vs. small firms), and methodological issues (e.g., self-report measures). By analyzing these contingencies, this study attempts to provide a basis on which to draw conclusions regarding some inconsistencies and debates in the CEP–CFP research. Some of the results of the moderator analysis suggest that small firms benefit from environmental performance as much or more than large firms, US firms seem to benefit more than international counterparts, and environmental performance seems to have the strongest influence on market-measures of financial performance. (shrink)

Split liver transplantation (SLT) provides an opportunity to divide a donor liver, offering transplants to two small patients (one or both could be a child) rather than keeping it whole and providing a transplant to a single larger adult patient. In this article, we attempt to address the following question that is identified by the Organ Procurement and Transplant Network and United Network for Organ Sharing: ‘Should a large liver always be split if medically safe?’ This article aims to (...) defend an answer—‘not always’—and clarify under what circumstances SLT is ethically desirable. Our answer will show why a more dynamic approach is needed to the ethics of SLT. First, we discuss a case that does not need a dynamic approach. Then, we explain what is meant by a dynamic approach and why it is needed. (shrink)

After encountering this book, you will never look at the tiniest sliver of your own backyard or neighborhood park the same way; instead, you will be stunned by the unexpected variety of species found in an area so small.

A configuration of infantile attributes including a large head, large eyes, with a small nose and mouth low on the head comprise the visual baby schema or Kindchenschema that English speakers call “cute.” In contrast to the stimulus gestalt that evokes it, the evoked emotional response to cuteness has been little studied, perhaps because the emotion has no specific name in English, Norwegian, or German. We hypothesize that cuteness typically evokes kama muta, a social-relational emotion that in other contexts (...) is often labeled in English as being moved or touched, heartwarming, nostalgia, patriotic feeling, being touched by the Spirit, the feels, etcetera. What evokes kama muta is sudden intensification of a communal sharing relationship, either communal sharing between the person and another, or communal sharing between observed others. In accord with kama muta theory, we hypothesize that a kama muta response to cuteness results from a sudden feeling of communal sharing with the cute target. In colloquial terms, the perceiver adores the cute kittens and their heart goes out to them. When a person perceives cute targets interacting affectionately - that is, intensifying communal sharing between them - this should strengthen a kama muta response. We experimentally investigated these predictions in two studies (N = 356). Study 1 revealed that videos of cute targets evoked significantly more kama muta than videos of targets that were not particularly cute. Study 2, pre-registered, found that, as hypothesized, when cute targets interacted affectionately they evoked more kama muta and were humanized more than when they were not interacting. We measured the level of kama muta by self-reports of sensations and signs and of feelings labelled heartwarming, being moved, and being touched. Participants' ratings of kama muta were positively correlated with reported cuteness. In addition, as in our previous research on kama muta elicited by other types of stimuli, trait empathic concern predicted kama muta responses and perceived cuteness. The studies thus provide first evidence that cute stimuli evoke the heartwarming emotion of kama muta. (shrink)

This paper explores the changes in cognitive function which occur as someone "loses consciousness" under anesthesia. Seven volunteers attempted a categorization task and a within-list recognition test while inhaling air, 0.2% isoflurane, and 0.4% isoflurane. In general, performance on these tests declined as the dose of anesthetic was increased and returned to baseline after 10 min of breathing air. A measure of auditory evoked responding termed "coherent frequency" showed parallel changes. At 0.2% isoflurane, subjects could still identify and respond to (...) category exemplars but showed impaired short-term memory function. Electrical stimulation at 0.4% isoflurane, intended to mimic the arousing effects of surgery, had a small, beneficial effect on performance. A mean of 63% of category exemplars was identified at this stage, but recognition memory for those exemplars was at chance on recovery. There was no evidence for learning of words presented at 0.8% isoflurane. (shrink)

The rural health context in the United States presents unique ethical challenges to its approximately 60 million residents, who represent about one quarter of the overall population and are distributed over three-quarters of the country’s land mass. The rural context is not only identified by the small population density and distance to an urban setting but also by a combination of social, religious, geographical, and cultural factors. Living in a rural setting fosters a sense of shared values and beliefs, (...) a strong work ethic, self-reliance, and a tendency for close-knit extended social structures where overlapping relationships are commonplace. (shrink)